Frontiers in Bioengineering and Biotechnology (Dec 2021)

Laser Additively Manufactured Iron-Based Biocomposite: Microstructure, Degradation, and In Vitro Cell Behavior

  • Youwen Yang,
  • Guoqing Cai,
  • Mingli Yang,
  • Dongsheng Wang,
  • Shuping Peng,
  • Shuping Peng,
  • Zhigang Liu,
  • Cijun Shuai,
  • Cijun Shuai

DOI
https://doi.org/10.3389/fbioe.2021.783821
Journal volume & issue
Vol. 9

Abstract

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A too slow degradation of iron (Fe) limits its orthopedic application. In this study, calcium chloride (CaCl2) was incorporated into a Fe-based biocomposite fabricated by laser additive manufacturing, with an aim to accelerate the degradation. It was found that CaCl2 with strong water absorptivity improved the hydrophilicity of the Fe matrix and thereby promoted the invasion of corrosive solution. On the other hand, CaCl2 could rapidly dissolve once contacting the solution and release massive chloride ion. Interestingly, the local high concentration of chloride ion effectively destroyed the corrosion product layer due to its strong erosion ability. As a result, the corrosion product layer covered on the Fe/CaCl2 matrix exhibited an extremely porous structure, thus exhibiting a significantly reduced corrosion resistance. Besides, in vivo cell testing proved that the Fe/CaCl2 biocomposite also showed favorable cytocompatibility.

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