GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

Dayana Abboud; Adrian F. Daly; Nadine Dupuis; Mohamed Ali Bahri; Asuka Inoue; Andy Chevigné; Fabien Ectors; Alain Plenevaux; Bernard Pirotte; Albert Beckers; Julien Hanson

doi:10.1038/s41467-020-18500-x

Nature Communications (Sep 2020)

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

Dayana Abboud,
Adrian F. Daly,
Nadine Dupuis,
Mohamed Ali Bahri,
Asuka Inoue,
Andy Chevigné,
Fabien Ectors,
Alain Plenevaux,
Bernard Pirotte,
Albert Beckers,
Julien Hanson

Affiliations

Dayana Abboud: Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège
Adrian F. Daly: Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège
Nadine Dupuis: Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège
Mohamed Ali Bahri: GIGA-CRC in vivo Imaging, University of Liège
Asuka Inoue: Graduate School of Pharmaceutical Sciences, Tohoku University
Andy Chevigné: Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health
Fabien Ectors: GIGA—Transgenics Platform, Liège University
Alain Plenevaux: GIGA-CRC in vivo Imaging, University of Liège
Bernard Pirotte: Laboratory of Medicinal Chemistry, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège
Albert Beckers: Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège
Julien Hanson: Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège

DOI: https://doi.org/10.1038/s41467-020-18500-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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