MOLECULES OF INTERCELLULAR ADHESION IN BLOOD SERA OF PERSONS EXPOSED TO MERCURY

Abstract

This work is aimed at the determination of the level of molecules of intercellular adhesion of sICAM-1 and sVCAM-1 in the persons exposed to mercury. All the examined persons (88 males of 31-62) were divided into three groups: the persons with the diagnosis of chronic mercury intoxication in the postponed postcontact period (1st group); the persons with the first revealed diagnosis (2nd group); the persons without professional disease working under harmful conditions for more than 5 years. Determination of the molecules was conducted using immune-enzymatic analysis method. The levels of sICAM-1 didn't differ in the 1st and 2nd groups and came to 466,2 and 430,2 ng/ml respectively, the level of sICAM-1 in the 3rd group was 219,1 ng/ml. The sVCAM-1 concentration was 337,8,126,8 and 327,4 ng/ml in the 1st, 2nd and 3rd group respectively. Increasing sVCAM-1 levels in the workers with long-term work period indicate the activation of endothelial vessel. Increased levels of sICAM-1 in patients with cardiovascular disease are related to the pathogenesis of cardiovascular disease or chronic mercury intoxication.

Keywords

• sicam-1
• svcam-1
• chronic exposure to mercury
• chronic mercury intoxication
• endothelial dysfunction
• inflammation
• molecules of intercellular adhesion
• sicam-1
• svcam-1