Study on Pharmacokinetics of Cefuroxime by Dynamics of Its Distribution in Oral Fluid of Patients with Sinusitis

Abstract

A method for quantitative determination of cefuroxime in mixed saliva of patients with sinusitis by using spectrophotometer Shimadzu UV-1800, combined with the IBM PC is described. The conditions of the determination were the following: λ=266 nm, a quartz cuvette, the analysis time of 10 minutes. The method for determination of cefuroxime is characterized by high specificity, accuracy, use of small amounts of oral fluid and expressivity. The method may be recommended for the use in the clinical practice for optimizing cefuroxime therapy in patients. The pharmacokinetics of cefuroxime was investigated by the dynamics of its distribution in the oral fluid of patients with various infectious-somatic disorders.

Keywords

• cefuroxime
• oral fluid
• pharmacokinetics
• uv spectroscopy