Research progress on the roles of angiopoietin-like protein 8 in the pathogenesis of cardiovascular diseases

Abstract

Angiopoietin-like protein 8(ANGPTL8) secreted by liver and adipose tissue, is a glycoprotein exerting paramount effects on facilitation of vascular remodeling and regulation of inflammatory response; ANGPTL8 is involved in the initiation and progression of cardiovascular diseases including coronary artery disease, hypertension, aortic aneurysm and pathological cardiac hypertrophy, and holds promise for being a new target for the prevention and treatment of cardiovascular diseases.

Keywords

• angiopoietin-like protein 8|coronary artery disease|hypertension|aortic aneurysm|pathological cardiac hypertrophy