Transcriptional response to stress is pre-wired by promoter and enhancer architecture

Anniina Vihervaara; Dig Bijay Mahat; Michael J. Guertin; Tinyi Chu; Charles G. Danko; John T. Lis; Lea Sistonen

doi:10.1038/s41467-017-00151-0

Nature Communications (Aug 2017)

Transcriptional response to stress is pre-wired by promoter and enhancer architecture

Anniina Vihervaara,
Dig Bijay Mahat,
Michael J. Guertin,
Tinyi Chu,
Charles G. Danko,
John T. Lis,
Lea Sistonen

Affiliations

Anniina Vihervaara: Faculty of Science and Engineering, Cell Biology, Åbo Akademi University
Dig Bijay Mahat: Department of Molecular Biology and Genetics, Cornell University
Michael J. Guertin: Department of Biochemistry and Molecular Genetics, University of Virginia
Tinyi Chu: Department of Biomedical Sciences, The Baker Institute for Animal Health, Cornell University
Charles G. Danko: Department of Biomedical Sciences, The Baker Institute for Animal Health, Cornell University
John T. Lis: Department of Molecular Biology and Genetics, Cornell University
Lea Sistonen: Faculty of Science and Engineering, Cell Biology, Åbo Akademi University

DOI: https://doi.org/10.1038/s41467-017-00151-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, untranscribed chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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