Functional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1α-expressing stem cells

Geng An; Feixiang Guo; Xuemin Liu; Zhifang Wang; Ye Zhu; Yong Fan; Chengkai Xuan; Yan Li; Hongkai Wu; Xuetao Shi; Chuanbin Mao

doi:10.1038/s41467-020-16192-x

Nature Communications (Jun 2020)

Functional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1α-expressing stem cells

Geng An,
Feixiang Guo,
Xuemin Liu,
Zhifang Wang,
Ye Zhu,
Yong Fan,
Chengkai Xuan,
Yan Li,
Hongkai Wu,
Xuetao Shi,
Chuanbin Mao

Affiliations

Geng An: Department of Reproductive Medicine Center, Third Affiliated Hospital of Guangzhou Medical University
Feixiang Guo: Department of Reproductive Medicine Center, Third Affiliated Hospital of Guangzhou Medical University
Xuemin Liu: National Engineering Research Centre for Tissue Restoration and Reconstruction and School of Material Science and Engineering, South China University of Technology
Zhifang Wang: National Engineering Research Centre for Tissue Restoration and Reconstruction and School of Material Science and Engineering, South China University of Technology
Ye Zhu: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma
Yong Fan: Department of Reproductive Medicine Center, Third Affiliated Hospital of Guangzhou Medical University
Chengkai Xuan: National Engineering Research Centre for Tissue Restoration and Reconstruction and School of Material Science and Engineering, South China University of Technology
Yan Li: Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University
Hongkai Wu: Department of Chemistry, The Hong Kong University of Science and Technology
Xuetao Shi: Department of Reproductive Medicine Center, Third Affiliated Hospital of Guangzhou Medical University
Chuanbin Mao: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma

DOI: https://doi.org/10.1038/s41467-020-16192-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Injury of corpus cavernosa results in erectile dysfunction, and repair leading to restoration of function is difficult. Here the authors construct 3D printed hydrogel constructs seeded with HIF-1α-expressing muscle derived stem cells to restore corpus function in a rabbit model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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