Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice

Saki Hirakata, MD; Hiroki Aoki, MD, PhD; Satoko Ohno-Urabe, MD, PhD; Michihide Nishihara, MD, PhD; Aya Furusho, MD, PhD; Norifumi Nishida, MD; Sohei Ito, MD; Makiko Hayashi, MD; Hideo Yasukawa, MD, PhD; Tsutomu Imaizumi, MD, PhD; Sinichi Hiromatsu, MD, PhD; Hiroyuki Tanaka, MD, PhD; Yoshihiro Fukumoto, MD, PhD

JACC: Basic to Translational Science (Feb 2020)

Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice

Saki Hirakata, MD,
Hiroki Aoki, MD, PhD,
Satoko Ohno-Urabe, MD, PhD,
Michihide Nishihara, MD, PhD,
Aya Furusho, MD, PhD,
Norifumi Nishida, MD,
Sohei Ito, MD,
Makiko Hayashi, MD,
Hideo Yasukawa, MD, PhD,
Tsutomu Imaizumi, MD, PhD,
Sinichi Hiromatsu, MD, PhD,
Hiroyuki Tanaka, MD, PhD,
Yoshihiro Fukumoto, MD, PhD

Affiliations

Saki Hirakata, MD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Hiroki Aoki, MD, PhD: Cardiovascular Research Institute, Kurume University, Kurume, Japan; Address for correspondence: Dr. Hiroki Aoki, Cardiovascular Research Institute, Kurume University, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan.
Satoko Ohno-Urabe, MD, PhD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Michihide Nishihara, MD, PhD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Aya Furusho, MD, PhD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Norifumi Nishida, MD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Sohei Ito, MD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Makiko Hayashi, MD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Hideo Yasukawa, MD, PhD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Tsutomu Imaizumi, MD, PhD: International University of Health and Welfare, Fukuoka, Japan
Sinichi Hiromatsu, MD, PhD: Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, Kurume, Japan
Hiroyuki Tanaka, MD, PhD: Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, Kurume, Japan
Yoshihiro Fukumoto, MD, PhD: Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

Journal volume & issue: Vol. 5, no. 2
pp. 126 – 144

Abstract

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Summary: Aortic dissection (AD) is the acute destruction of aortic wall and is reportedly induced by inflammatory response. Here we investigated the role of smooth muscle Socs3 (a negative regulator of Janus kinases/signal transducer and activator of transcription signaling) in AD pathogenesis using a mouse model generated via β-aminopropionitrile and angiotensin II infusion. Socs3 deletion specifically in smooth muscle cells yielded a chronic inflammatory response of the aortic wall, which was associated with increased fibroblasts, reinforced aortic tensile strength, and less-severe tissue destruction. Although an acute inflammatory response is detrimental in AD, smooth muscle-regulated inflammatory response seemed protective against AD. Key Words: aortic dissection, inflammation, Jak/Stat, smooth muscle cells

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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