COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Abstract

Autoimmunity following COVID-19 vaccination has been reported. Herein, a 79-year-old man with clinical and immunological features of autoimmune hepatitis type 1 after ChAdOx1 nCoV-19 vaccination is presented. Clinical manifestations rapidly remitted after the instauration of immunomodulatory management. This case, together with a comprehensive review of the literature, illustrates the association between COVID-19 vaccines and the development of autoimmune conditions.

Keywords

• Autoimmune hepatitis
• COVID-19
• SARS-CoV-2
• AstraZeneca
• ChAdOx1 nCoV-19
• AZD1222