261 Synergistic antitumor effects of mouse mesothelin-directed CAR (mmeso-CAR) T cells and αCD40 in a syngeneic model of PDAC

• Carl H June,
• John Scholler,
• Joseph A Fraietta,
• Andrew Rech,
• Daniel Martinez,
• David Mai,
• Omar Johnson,
• Khatuna Gabunia,
• Regina M Young,
• Charles-Antoine Assenmacher,
• Enrico Radaelli,
• Giulia Golinelli,
• Ting-Jia Fan,
• Jordan Reff,
• Zachary Ferraro,
• Decheng Song,
• Aasha Gupta,
• Mansi Deshmukh,
• He N Xu,
• Wesley V Wilson,
• Julia C Tchou,
• Bruce L Levine

Affiliations

Carl H June

6Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

John Scholler

Center for Cellular Immunotherapies, Perlman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

Joseph A Fraietta

1Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

Andrew Rech

Aff5 grid.25879.310000000419368972University of Pennsylvania Philadelphia PA USA

Daniel Martinez

Medical Department, Médecins Sans Frontières, Geneva, Switzerland

David Mai

University of Pennsylvania, Philadelphia, PA, USA

Omar Johnson

University of Pennsylvania, Philadelphia, PA, USA

Khatuna Gabunia

1University of Pennsylvania, Philadelphia, PA, USA

Regina M Young

University of Pennsylvania, Philadelphia, PA, USA

Charles-Antoine Assenmacher

2Comparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine at the University of Pennsylvania, Philadelphia, PA, USA

Enrico Radaelli

4Comparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine at the University of Pennsylvania, Philadelphia, PA, USA

Giulia Golinelli

1University of Pennsylvania, Philadelphia, PA, USA

Ting-Jia Fan

1University of Pennsylvania, Philadelphia, PA, USA

Jordan Reff

1University of Pennsylvania, Philadelphia, PA, USA

Zachary Ferraro

1University of Pennsylvania, Philadelphia, PA, USA

Decheng Song

1University of Pennsylvania, Philadelphia, PA, USA

Aasha Gupta

1University of Pennsylvania, Philadelphia, PA, USA

Mansi Deshmukh

1University of Pennsylvania, Philadelphia, PA, USA

He N Xu

1University of Pennsylvania, Philadelphia, PA, USA

Wesley V Wilson

1University of Pennsylvania, Philadelphia, PA, USA

Julia C Tchou

1University of Pennsylvania, Philadelphia, PA, USA

Bruce L Levine

1University of Pennsylvania, Philadelphia, PA, USA