Frontiers in Neuroscience (Oct 2022)
A physical perspective to understand myelin II: The physical origin of myelin development
Abstract
The physical principle of myelin development is obtained from our previous study by explaining Peter’s quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E, to explain more phenomena about myelin development systematically. Specifically, the g-ratio and the fate of the Schwann cell’s differentiation are explained in terms of the E-field. Moreover, an experiment is proposed to validate this theory.
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