Nature Communications (Sep 2021)
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
- John DeSisto,
- John T. Lucas,
- Ke Xu,
- Andrew Donson,
- Tong Lin,
- Bridget Sanford,
- Gang Wu,
- Quynh T. Tran,
- Dale Hedges,
- Chih-Yang Hsu,
- Gregory T. Armstrong,
- Michael Arnold,
- Smita Bhatia,
- Patrick Flannery,
- Rakeb Lemma,
- Lakotah Hardie,
- Ulrich Schüller,
- Sujatha Venkataraman,
- Lindsey M. Hoffman,
- Kathleen Dorris,
- Jean M. Mulcahy Levy,
- Todd C. Hankinson,
- Michael Handler,
- Arthur K. Liu,
- Nicholas Foreman,
- Rajeev Vibhakar,
- Kenneth Jones,
- Sariah Allen,
- Jinghui Zhang,
- Suzanne J. Baker,
- Thomas E. Merchant,
- Brent A. Orr,
- Adam L. Green
Affiliations
- John DeSisto
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- John T. Lucas
- Department of Radiation Oncology, St. Jude Children’s Research Hospital
- Ke Xu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Andrew Donson
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Tong Lin
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Bridget Sanford
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Gang Wu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Quynh T. Tran
- Department of Pathology, St. Jude Children’s Research Hospital
- Dale Hedges
- Department of Radiation Oncology, St. Jude Children’s Research Hospital
- Chih-Yang Hsu
- Department of Radiation Oncology, St. Jude Children’s Research Hospital
- Gregory T. Armstrong
- Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital
- Michael Arnold
- Department of Pathology, Nationwide Children’s Hospital
- Smita Bhatia
- Childhood Cancer Survivor Study, St. Jude Children’s Research Hospital
- Patrick Flannery
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Rakeb Lemma
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Lakotah Hardie
- Children’s Hospital Colorado
- Ulrich Schüller
- Institute of Neuropathology and Department of Pediatric Hematology and Oncology, University Medical Center, Children’s Cancer Center
- Sujatha Venkataraman
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Lindsey M. Hoffman
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Kathleen Dorris
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Jean M. Mulcahy Levy
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Todd C. Hankinson
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Michael Handler
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Arthur K. Liu
- Children’s Hospital Colorado
- Nicholas Foreman
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Rajeev Vibhakar
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Kenneth Jones
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- Sariah Allen
- Department of Pathology, St. Jude Children’s Research Hospital
- Jinghui Zhang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Suzanne J. Baker
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Thomas E. Merchant
- Department of Radiation Oncology, St. Jude Children’s Research Hospital
- Brent A. Orr
- Department of Pathology, St. Jude Children’s Research Hospital
- Adam L. Green
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25709-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. In the largest study to date, we report the results of DNA methylation profiling, RNA-Seq and genomic sequencing of 32 RIG tumors, and an in vitro drug screen in two RIG cell lines.
