Frontiers in Sleep (May 2024)
Validation of spectral sleep scoring with polysomnography using forehead EEG device
Abstract
IntroductionVisual scoring of sleep electroencephalography (EEG) has long been considered the gold standard for sleep staging. However, it has several drawbacks, including high cost, time-intensiveness, vulnerability to human variability, discomfort to patients, lack of visualization to validate the hypnogram, and no acknowledgment of differences between delta and slow oscillation deep sleep. This report highlights a spectral scoring approach that addresses all these shortcomings of visual scoring. Past algorithms have used spectral information to help classify traditional visual stages. The current method used the clearly visible spectral patterns to develop new spectral stages, which are similar to but not the same as visual stages. Importantly, spectral scoring delivers both a hypnogram and a whole-night spectrogram, which can be visually inspected to ensure accurate scoring.MethodsThis study compared traditional visual scoring of 32-channel polysomnography with forehead-only spectral scoring from an EEG patch worn concurrently. The PSG was visually scored by trained technicians and the forehead patch was scored spectrally. Because non-rapid eye movement (NREM) stage divisions in spectral scoring are not based on visual NREM stages, the agreements are not expected to be as high as other automated sleep scoring algorithms. Rather, they are a guide to understanding spectral stages as they relate to the more widely understood visual stages and to emphasize reasons for the differences.ResultsThe results showed that visual REM was highly recognized as spectral REM (89%). Visual wake was only scored as spectral Wake 47% of the time, partly because of excessive visual scoring of wake during Light and REM sleep. The majority of spectral Light (predominance of spindle power) was scored as N2 (74%), while less N2 was scored as Light (65%), mostly because of incorrect visual staging of Lo Deep sleep due to high-pass filtering. N3 was scored as both Hi Deep (13 Hz power, 42%) and Lo Deep (0–1 Hz power, 39%), constituting a total of 81% of N3.DiscussionThe results show that spectral scoring better identifies clinically relevant physiology at a substantially lower cost and in a more reproducible fashion than visual scoring, supporting further work exploring its use in clinical and research settings.
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