Survival Impact of Postoperative Adjuvant Radiotherapy for Treatment of Advanced Stage Maxillary Sinus Cancer Patients

Abstract

Introduction: Maxillary sinus cancer is a rare disease and usually present in advanced stage. Limited clinical data exists from India about the use of adjuvant radiotherapy in advanced cases and survival thereafter. Aim: To study survival and identify prognostic factors of importance in patients irradiated postoperatively for advanced stage maxillary sinus carcinoma. Materials and Methods: Medical records of 25 patients of advanced stage maxillary sinus carcinoma treated with curative intent from January 2011 to November 2016 were analysed retrospectively. All the patients underwent primary surgery followed by postoperative adjuvant radiotherapy. Survival analysis was done using Kaplan-Meier method. Results: All patients presented with advanced disease Stage III or IV; nodal involvement was observed in 5 (20%) patients. The three-year overall survival after surgery and postoperative radiotherapy with or without concurrent chemotherapy was 74%. Median survival was 17 months. Most common pattern of recurrence was at the primary site, observed in 5 (20%) patients. Lymph node involvement, pT4 lesion, surgical margins positive, depth of invasion >10 mm, high grade, lymphovascular/perineural invasion were prognostic factors of importance. Conclusion: Primary surgical treatment of maxillary sinus carcinoma in advanced stage followed by postoperative adjuvant radiotherapy is a good treatment option.

Keywords

• carcinoma
• maxilla
• survival analysis