Json-GUI is an AngularJS front-end module that dynamically generates form-based web interfaces. Starting from a formal JSON configuration object describing a list of inputs, Json-GUI is able to build a form frame interface at runtime, with standard and personalized validation rules, giving the possibility to define constraints between input fields. Validated data are stored as Json objects or text files. Json-GUI has been exploited by scientific communities to effectively reduce the development and maintenance of customized user interfaces in science gateways. Moreover, Json-GUI can also be employed in the development of general-purpose Web forms. Keywords: AngularJS, Web form, Science gateways