Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors

Holger Dannenberg; Kimberly Young; Michael Hasselmo

doi:10.3389/fncir.2017.00102

Frontiers in Neural Circuits (Dec 2017)

Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors

Holger Dannenberg,
Kimberly Young,
Michael Hasselmo

Affiliations

Holger Dannenberg: enter for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, United States
Kimberly Young: enter for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, United States
Michael Hasselmo: enter for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, United States

DOI: https://doi.org/10.3389/fncir.2017.00102
Journal volume & issue: Vol. 11

Abstract

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This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons.

Published in Frontiers in Neural Circuits

ISSN: 1662-5110 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/neural-circuits/

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