Formation of Extracellular Traps - the Effective Mechanism of Organism Protection from Pathogen

Abstract

Summarized and analyzed are modern literature data on capability of cells (neutrophils, eosinophils and labrocytes) realizing the mechanisms of innate immunity, to form extracellular traps that capture and kill pathogens by secretion of DNA and antibacterial granules content into extracellular space. The efficiency of capture and bacterial clearance is higher in extracellular traps than that in phagocytosis. The mechanism of extracellular bactericidal activity is supposed to play an important role in protection of organism from bacteria which are resistant to phagocytosis by leukocytes.

Keywords

• extracellular space
• innate immunity
• bacterial infection
• dna secretion
• secretory degranulation
• leukocyte proteases
• antibacterial peptides