P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Ping Hu; Angel R. Nebreda; Helmut Hanenberg; Garrett H. Kinnebrew; Mircea Ivan; Mervin C. Yoder; Marie-Dominique Filippi; Hal E. Broxmeyer; Reuben Kapur

doi:10.1038/s41467-018-05955-2

Nature Communications (Aug 2018)

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Ping Hu,
Angel R. Nebreda,
Helmut Hanenberg,
Garrett H. Kinnebrew,
Mircea Ivan,
Mervin C. Yoder,
Marie-Dominique Filippi,
Hal E. Broxmeyer,
Reuben Kapur

Affiliations

Ping Hu: Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis
Angel R. Nebreda: Institute for Research in Biomedicine (IRB Barcelona). Barcelona Institute of Science and Technology
Helmut Hanenberg: Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen
Garrett H. Kinnebrew: Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis
Mircea Ivan: Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis
Mervin C. Yoder: Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis
Marie-Dominique Filippi: Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Research Foundation, University of Cincinnati College of Medicine
Hal E. Broxmeyer: Department of Microbiology/Immunology, Indiana University School of Medicine
Reuben Kapur: Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis

DOI: https://doi.org/10.1038/s41467-018-05955-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and thus identify putative targets for the treatment of anemic disorders resistant to EPO.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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