Molecules (Aug 2021)

Solvatomorphism of Moxidectin

  • Toni Grell,
  • Mauro Barbero,
  • Franco Pattarino,
  • Giovanni Battista Giovenzana,
  • Valentina Colombo

DOI
https://doi.org/10.3390/molecules26164869
Journal volume & issue
Vol. 26, no. 16
p. 4869

Abstract

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The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

Keywords