Correlations between heart rate variability, renin activity and plasma aldosteron concentration in chronic glomerulonephritis with intact function of the kidneys

Abstract

Aim. To study correlations between heart rate variability (HRV), renin activity and blood aldosteron in chronic glomerulonephritis (CGN) with intact renal function. Material and methods. A total of 136 CGN patients with intact renal function were examined (100 hypertensive and 36 normotensive patients). HRV was studied with 24-h ECG monitoring. Active renin (AR) and aldosteron in blood plasma was studied with radioimmunoassay. Results. The analysis of HRV detected a progressive attenuation of vegetative impacts on the cardiovascular system with aggravation of hypertension in CGN patients with intact renal function. In hypertension of the second and third degree AR and aldosteron levels increased. Conclusion. With arterial hypertension progression in CGN patients with intact renal function, vegetative impacts on the cardiovascular system diminished while the levels of active renin and aldosterone rose.

Keywords

• chronic glomerulonephritis
• arterial hypertension
• heart rate variability
• renin
• aldosterone