Management of patients with diabetic polyneuropathy: current guidelines for diagnosis and treatment, prospects for pharmacotherapy

Abstract

Early diagnosis and timely rational therapy of DP allow to prevent disability, increase duration and improve the quality of life of patients with diabetes mellitus (DM). The most feasible practical diagnostic algorithm for DP is still a matter of debate. The article focuses on the most common form of DP - diabetic distal symmetrical sensorimotor polyneuropathy (DSSP). Effective non-pharmaceutical methods to improve the course of DP and DSSP include optimum control of blood glucose level, educational programs, lifestyle (diet, maintaining or achieving a healthy weight, therapeutic exercises, maintaining everyday activity) and, when indicated, cognitive-behavioral therapy. Symptomatic treatment of neuropathic pain in DSSP achieved significant success, however it fails to inhibit the damage to the peripheral nerves. The search for therapies aimed at changing the course of DSSP continues. In Russia, alpha-lipoic acid and vitamin B complex are discussed as possible pathogenetic treatments of DSSP. Cocarnit is a combination medicine containing vitamins B and metabolically active substances. Prospects for the use of the drug in the treatment of patients with DSSP are considered.

Keywords

• диабетическая полиневропатия
• болевая диабетическая полиневропатия
• диагностика
• лечение
• когнитивно-поведенческая терапия
• кокарнит
• diabetic polyneuropathy
• painful diabetic polyneuropathy
• diagnosis
• treatment
• cognitive-behavioral therapy
• cocarnit