SELENOF gene as a quintessential target in oral squamous cell carcinoma

Abstract

Goal of the Perspective: Antioxidant mechanism are irreversibly damaged and cause cellular and genetic changes in oral cancer. Selenium is an essential component of selenoproteins that help to make DNA and protect against cell damage. Discussion: Mutation or altered SELENOF gene expression eventually leads to the oxidative damage to DNA due to alteration in anti-oxidative mechanism of selenoproteins and potentially increase risk of cancer development. Selenium substantially suppressed cell proliferation of cancerous cells in vitro and they could effectively produce oxidative stress and trigger apoptosis in oral cancer cells, hence inhibiting the oral cancer to some extent. Conclusion: Considering the beneficial anti-oxidant activities, it prudent to explore the possibility of targeting the SELENOF gene thereby enhancing the anti-tumor activity through Redox mechanism in OSCC. Interactome analysis revealed significant Hub genes and druggable sites of SELENOF in management of Oral squamous cell carcinoma.

Keywords

• SELENOF
• Oral squamous cell carcinoma
• Targeted therapy