Nature Communications (Dec 2021)
Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia
- Afonso R. M. Almeida,
- João L. Neto,
- Ana Cachucho,
- Mayara Euzébio,
- Xiangyu Meng,
- Rathana Kim,
- Marta B. Fernandes,
- Beatriz Raposo,
- Mariana L. Oliveira,
- Daniel Ribeiro,
- Rita Fragoso,
- Priscila P. Zenatti,
- Tiago Soares,
- Mafalda R. de Matos,
- Juliana Ronchi Corrêa,
- Mafalda Duque,
- Kathryn G. Roberts,
- Zhaohui Gu,
- Chunxu Qu,
- Clara Pereira,
- Susan Pyne,
- Nigel J. Pyne,
- Vasco M. Barreto,
- Isabelle Bernard-Pierrot,
- Emannuelle Clappier,
- Charles G. Mullighan,
- Ana R. Grosso,
- J. Andrés Yunes,
- João T. Barata
Affiliations
- Afonso R. M. Almeida
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- João L. Neto
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Ana Cachucho
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Mayara Euzébio
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Xiangyu Meng
- Institut Curie, PSL Research University, CNRS, UMR144, Equipe Labellisée Ligue contre le Cancer
- Rathana Kim
- Hematology Laboratory, Saint-Louis Hospital, AP-HP, Paris, France, and Saint-Louis Research Institute, Université de Paris, INSERM U944/Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7212
- Marta B. Fernandes
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Beatriz Raposo
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Mariana L. Oliveira
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Daniel Ribeiro
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Rita Fragoso
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Priscila P. Zenatti
- Centro Infantil Boldrini
- Tiago Soares
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Mafalda R. de Matos
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Juliana Ronchi Corrêa
- Centro Infantil Boldrini
- Mafalda Duque
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Kathryn G. Roberts
- Department of Pathology and Hematological Malignancies Program, St. Jude Children’s Research Hospital
- Zhaohui Gu
- Department of Pathology and Hematological Malignancies Program, St. Jude Children’s Research Hospital
- Chunxu Qu
- Department of Pathology and Hematological Malignancies Program, St. Jude Children’s Research Hospital
- Clara Pereira
- Smurfit Institute of Genetics, Trinity College Dublin, University of Dublin
- Susan Pyne
- Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde
- Nigel J. Pyne
- Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde
- Vasco M. Barreto
- DNA Breaks Laboratory, CEDOC - Chronic Diseases Research Center, NOVA Medical School - Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
- Isabelle Bernard-Pierrot
- Institut Curie, PSL Research University, CNRS, UMR144, Equipe Labellisée Ligue contre le Cancer
- Emannuelle Clappier
- Hematology Laboratory, Saint-Louis Hospital, AP-HP, Paris, France, and Saint-Louis Research Institute, Université de Paris, INSERM U944/Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7212
- Charles G. Mullighan
- Department of Pathology and Hematological Malignancies Program, St. Jude Children’s Research Hospital
- Ana R. Grosso
- UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa
- J. Andrés Yunes
- Centro Infantil Boldrini
- João T. Barata
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- DOI
- https://doi.org/10.1038/s41467-021-27197-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Interleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell acute lymphoblastic leukaemia.
