Dataset of mouse hippocampus profiled by LC–MS/MS for label-free quantitation
Jane A. English,
Caitriona Scaife,
Akiko Harauma,
Melanie Focking,
Kieran Wynne,
Gerard Cagney,
Toru Moriguchi,
David R. Cotter
Affiliations
Jane A. English
Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland; Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Caitriona Scaife
Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Akiko Harauma
Department of Food and Life Science, Azabu University, Sagamihara, Japan
Melanie Focking
Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland
Kieran Wynne
Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Gerard Cagney
Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Toru Moriguchi
Department of Food and Life Science, Azabu University, Sagamihara, Japan
David R. Cotter
Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland
This dataset reports on the analysis of mouse hippocampus by LC–MS/MS, from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq). Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins, 115 of which were found to be differentially expressed between the two dietary groups (n=8 per group). This data article refers to the research article “Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus” (English et al., 2013 [1]), in which a more comprehensive interpretation and analysis of the data is given. Keywords: Mouse, Brain, Hippocampus, Proteins, Proteomics, Mass spectrometry, Omega-3 deficiency
