PLoS ONE (Jan 2012)

Rise of CC398 lineage of Staphylococcus aureus among Infective endocarditis isolates revealed by two consecutive population-based studies in France.

  • Anne Tristan,
  • Jean-Philippe Rasigade,
  • Esmée Ruizendaal,
  • Frédéric Laurent,
  • Michèle Bes,
  • Hélène Meugnier,
  • Gérard Lina,
  • Jerome Etienne,
  • Marie Celard,
  • Pierre Tattevin,
  • Stefan Monecke,
  • Vincent Le Moing,
  • François Vandenesch,
  • French AEPEI study Group on Infective Endocarditis

DOI
https://doi.org/10.1371/journal.pone.0051172
Journal volume & issue
Vol. 7, no. 12
p. e51172

Abstract

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Staphylococcus aureus isolates from two prospective studies on infective endocarditis (IE) conducted in 1999 and 2008 and isolated from non-IE bacteremia collected in 2006 were spa-typed and their virulence factors were analyzed with a microarray. Both populations were genetically diverse, with no virulence factors or genotypes significantly more associated with the IE isolates compared with the non-IE isolates. The population structure of the IE isolates did not change much between 1999 and 2008, with the exception of the appearance of CC398 methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for 5.6% of all cases in 2008. In 1999, this lineage was responsible for no cases. The increasing prevalence of S. aureus in IE is apparently not the result of a major change in staphylococcal population structure over time, with the exception of the emerging CC398 MSSA lineage.