Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination

Darpan Saraswat; Hani J. Shayya; Jessie J. Polanco; Ajai Tripathi; R. Ross Welliver; Suyog U. Pol; Richard A. Seidman; Jacqueline E. Broome; Melanie A. O’Bara; Toin H. van Kuppervelt; Joanna J. Phillips; Ranjan Dutta; Fraser J. Sim

doi:10.1038/s41467-021-22263-4

Nature Communications (Mar 2021)

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination

Darpan Saraswat,
Hani J. Shayya,
Jessie J. Polanco,
Ajai Tripathi,
R. Ross Welliver,
Suyog U. Pol,
Richard A. Seidman,
Jacqueline E. Broome,
Melanie A. O’Bara,
Toin H. van Kuppervelt,
Joanna J. Phillips,
Ranjan Dutta,
Fraser J. Sim

Affiliations

Darpan Saraswat: Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at Buffalo
Hani J. Shayya: Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at Buffalo
Jessie J. Polanco: Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
Ajai Tripathi: Department of Neuroscience, Lerner Research Institute
R. Ross Welliver: Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
Suyog U. Pol: Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at Buffalo
Richard A. Seidman: Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
Jacqueline E. Broome: Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at Buffalo
Melanie A. O’Bara: Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at Buffalo
Toin H. van Kuppervelt: Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Joanna J. Phillips: Department of Neurological Surgery, University of California
Ranjan Dutta: Department of Neuroscience, Lerner Research Institute
Fraser J. Sim: Department of Pharmacology and Toxicology, Jacob’s School of Medicine and Biomedical Sciences, University at Buffalo

DOI: https://doi.org/10.1038/s41467-021-22263-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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