Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection

Patrick Vigneault; Sandrine Parent; Pushpinder Kanda; Connor Michie; Darryl R. Davis; Stanley Nattel

doi:10.1038/s41467-021-25180-8

Nature Communications (Aug 2021)

Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection

Patrick Vigneault,
Sandrine Parent,
Pushpinder Kanda,
Connor Michie,
Darryl R. Davis,
Stanley Nattel

Affiliations

Patrick Vigneault: Research Center and Department of Medicine, Montreal Heart Institute, Université de Montréal
Sandrine Parent: Division of Cardiology, Department of Medicine, University of Ottawa
Pushpinder Kanda: Division of Cardiology, Department of Medicine, University of Ottawa
Connor Michie: Division of Cardiology, Department of Medicine, University of Ottawa
Darryl R. Davis: Division of Cardiology, Department of Medicine, University of Ottawa
Stanley Nattel: Research Center and Department of Medicine, Montreal Heart Institute, Université de Montréal

DOI: https://doi.org/10.1038/s41467-021-25180-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Strategies to improve the function of damaged hearts with progenitor cells have stalled. Here, the authors show that gene transfer of a calcium-dependent potassium channel enhances the functional properties and ability of explant-derived cells to improve heart function after a heart attack.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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