Comparative Effects of Ginseng Extract and Green Tea with Pomeol Bruler on C-Reactive Protein and Liver Enzymes of Rats Fed a High-Fat Diet

Abstract

Background and Objective: Many studies have been done on the effects of ginseng and green tea on inflammatory factors and liver enzymes, but no research has yet studied the comparative effects of ginseng and green tea extracts with Pomeol Breuler on C-reactive protein (CRP) and liver enzymes in hyperlipidemic rats. This study was done to evaluate the effects of ginseng and green tea extracts in comparison with Pomeol Bruler on CRP and liver enzymes in hyperlipidemic rats. Methods: In this experimental study, 42 male Wistar rats were randomly allocated into 7 groups. Animals in group 1 (control group) received a normal diet. The experimental groups 2-7 received a high-fat diet for a month. The groups were treated with the extract for 8 weeks and by intraperitoneal injection. Groups 1 and 2 received 77.5 mg/kg/day and 155 mg/kg/day green tea extract, respectively. Groups 3 and 4 received 103.3 mg/kg/day and 206.6 mg/kg/day ginseng extract, respectively. Group 5 received 0.16 g/kg/day of Pomeol Bruler, and group 6 received green tea extract (155 mg/kg/day) and ginseng extract (206.6 mg/kg/day). At the end of the treatment, the level of CRP and liver enzymes including aspartate transaminase (AST) and alanine transaminase (ALT) were measured. Results: The level of CRP was significantly reduced in the rats treated with ginseng, green tea, and Pomeol Bruler compared with the control group (P<0.05). The level of AST and ALT did not differ significantly between the ginseng, green tea, Pomeol Bruler, and control groups. Conclusion: The combined use of ginseng and green tea with Pomeol Breuler for 8 weeks may reduce inflammatory factors but does not affect liver enzymes.

Keywords

• ginseng
• green tea extract
• c-reactive protein
• alanine transaminase
• aspartate transaminase