Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

Qinglei Hang; Liyong Zeng; Li Wang; Litong Nie; Fan Yao; Hongqi Teng; Yalan Deng; Shannon Yap; Yutong Sun; Steven J. Frank; Junjie Chen; Li Ma

doi:10.1038/s41467-021-24298-z

Nature Communications (Jun 2021)

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

Qinglei Hang,
Liyong Zeng,
Li Wang,
Litong Nie,
Fan Yao,
Hongqi Teng,
Yalan Deng,
Shannon Yap,
Yutong Sun,
Steven J. Frank,
Junjie Chen,
Li Ma

Affiliations

Qinglei Hang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Liyong Zeng: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Li Wang: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
Litong Nie: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Fan Yao: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Hongqi Teng: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Yalan Deng: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Shannon Yap: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Yutong Sun: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Steven J. Frank: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
Junjie Chen: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Li Ma: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-021-24298-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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The molecular mechanisms underlying cancer cell radioresistance need to be elucidated. In this study, the authors show that the microRNA biogenesis factor DGCR8 is stabilized by USP51 and ATM upon irradiation and by consequence it promotes the repair of DNA double-strand breaks and radioresistance by recruiting RNF168 to sites of damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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