Extraskeletal Ewing sarcoma of the parapharyngeal space with a unique translocation, t(19;22) (q13.4;q12.2)

Gloria Ramos-Rivera; Esther Adler; K.H. Ramesh; Bradley Schiff; Mark Suhrland; Samer Khader

doi:10.1016/j.ehpc.2015.07.003

Human Pathology: Case Reports (Jun 2016)

Extraskeletal Ewing sarcoma of the parapharyngeal space with a unique translocation, t(19;22) (q13.4;q12.2)

Gloria Ramos-Rivera,
Esther Adler,
K.H. Ramesh,
Bradley Schiff,
Mark Suhrland,
Samer Khader

Affiliations

Gloria Ramos-Rivera: Montefiore Medical Center/Department of Pathology, The University Hospital for Albert Einstein College of Medicine, 111 E. 210th Street, Central 410, Bronx, NY 10467, United States
Esther Adler: Kings County Hospital Center, P-Building, 451 Clarkson Avenue, Brooklyn, NY 11203, United States
K.H. Ramesh: Montefiore Medical Center/Department of Pathology, The University Hospital for Albert Einstein College of Medicine, 111 E. 210th Street, Central 410, Bronx, NY 10467, United States
Bradley Schiff: Montefiore Medical Center/Department of Otolaryngology, Head & Neck Surgery, The University Hospital for Albert Einstein College of Medicine, Montefiore Greene Medical Arts Pavilion, 3400 Bainbridge Avenue, Bronx, NY 10467-2404, United States
Mark Suhrland: Montefiore Medical Center/Department of Pathology, The University Hospital for Albert Einstein College of Medicine, 111 E. 210th Street, Central 410, Bronx, NY 10467, United States
Samer Khader: Montefiore Medical Center/Department of Pathology, The University Hospital for Albert Einstein College of Medicine, 111 E. 210th Street, Central 410, Bronx, NY 10467, United States

DOI: https://doi.org/10.1016/j.ehpc.2015.07.003
Journal volume & issue: Vol. 4, no. C
pp. 38 – 41

Abstract

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Extraskeletal Ewing sarcomas of the parapharyngeal space are extremely rare. It has been documented that Ewing sarcomas are morphologically and molecularly indistinguishable regardless of the tissue of origin. Around 85% of Ewing sarcomas are associated with translocation t(11;22)(q24.1;12.2) generating the EWSR1–FLI1 fusion oncoprotein. We report a case of an extraskeletal Ewing sarcoma arising in the parapharyngeal space with a unique translocation: t(19; 22) (q13.4;q12.2). To our knowledge this is the first case of an extraskeletal Ewing sarcoma exhibiting this translocation.

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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