Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum

Felix Evers; Alfredo Cabrera-Orefice; Dei M. Elurbe; Mariska Kea-te Lindert; Sylwia D. Boltryk; Till S. Voss; Martijn A. Huynen; Ulrich Brandt; Taco W. A. Kooij

doi:10.1038/s41467-021-23919-x

Nature Communications (Jun 2021)

Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum

Felix Evers,
Alfredo Cabrera-Orefice,
Dei M. Elurbe,
Mariska Kea-te Lindert,
Sylwia D. Boltryk,
Till S. Voss,
Martijn A. Huynen,
Ulrich Brandt,
Taco W. A. Kooij

Affiliations

Felix Evers: Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Alfredo Cabrera-Orefice: Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Dei M. Elurbe: Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Mariska Kea-te Lindert: Electron Microscopy Center, RTC Microscopy, Radboud Institute of Molecular Life Sciences, Radboud University Medical Center
Sylwia D. Boltryk: Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute
Till S. Voss: Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute
Martijn A. Huynen: Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Ulrich Brandt: Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Taco W. A. Kooij: Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center

DOI: https://doi.org/10.1038/s41467-021-23919-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Applying complexome profiling, Evers et al. unravel the composition of mitochondrial oxidative phosphorylation complexes in P. falciparum asexual and sexual blood stages. Abundance of these complexes differs between both stages, supporting the hypothesis that a mitochondrial metabolic switch is central to gametocyte development and functioning.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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