Nature Communications (Nov 2018)

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

  • Joshua Moss,
  • Judith Magenheim,
  • Daniel Neiman,
  • Hai Zemmour,
  • Netanel Loyfer,
  • Amit Korach,
  • Yaacov Samet,
  • Myriam Maoz,
  • Henrik Druid,
  • Peter Arner,
  • Keng-Yeh Fu,
  • Endre Kiss,
  • Kirsty L. Spalding,
  • Giora Landesberg,
  • Aviad Zick,
  • Albert Grinshpun,
  • A. M. James Shapiro,
  • Markus Grompe,
  • Avigail Dreazan Wittenberg,
  • Benjamin Glaser,
  • Ruth Shemer,
  • Tommy Kaplan,
  • Yuval Dor

DOI
https://doi.org/10.1038/s41467-018-07466-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.