Nature Communications (Aug 2019)
Proteogenomic landscape of squamous cell lung cancer
- Paul A. Stewart,
- Eric A. Welsh,
- Robbert J. C. Slebos,
- Bin Fang,
- Victoria Izumi,
- Matthew Chambers,
- Guolin Zhang,
- Ling Cen,
- Fredrik Pettersson,
- Yonghong Zhang,
- Zhihua Chen,
- Chia-Ho Cheng,
- Ram Thapa,
- Zachary Thompson,
- Katherine M. Fellows,
- Jewel M. Francis,
- James J. Saller,
- Tania Mesa,
- Chaomei Zhang,
- Sean Yoder,
- Gina M. DeNicola,
- Amer A. Beg,
- Theresa A. Boyle,
- Jamie K. Teer,
- Yian Ann Chen,
- John M. Koomen,
- Steven A. Eschrich,
- Eric B. Haura
Affiliations
- Paul A. Stewart
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Eric A. Welsh
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Robbert J. C. Slebos
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Bin Fang
- Proteomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute
- Victoria Izumi
- Proteomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute
- Matthew Chambers
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Guolin Zhang
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Ling Cen
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Fredrik Pettersson
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Yonghong Zhang
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Zhihua Chen
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Chia-Ho Cheng
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Ram Thapa
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Zachary Thompson
- Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute
- Katherine M. Fellows
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Jewel M. Francis
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- James J. Saller
- Department of Anatomical Pathology, H. Lee Moffitt Cancer Center and Research Institute
- Tania Mesa
- Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute
- Chaomei Zhang
- Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute
- Sean Yoder
- Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute
- Gina M. DeNicola
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Amer A. Beg
- Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
- Theresa A. Boyle
- Department of Anatomical Pathology, H. Lee Moffitt Cancer Center and Research Institute
- Jamie K. Teer
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute
- Yian Ann Chen
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute
- John M. Koomen
- Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Steven A. Eschrich
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute
- Eric B. Haura
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-11452-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Squamous cell lung cancer has dismal prognosis due to the dearth of effective treatments. Here, the authors perform an integrated proteogenomic analysis of the disease, revealing three proteomics-based subtypes and suggesting potential therapeutic opportunities.
