The Association Between Salivary Procalcitonin and Periodontitis in Type 2 Diabetic Patients

Abstract

One of the most prevalent conditions that affects teeth, periodontitis causes the surrounding and supporting tooth structure to be destroyed. Procalcitonin may be a helpful marker to determine the severity of infection, forecast the prognosis, and track the effectiveness of treatment. Aim of the study: To assess the association between the salivary procalcitonin level and periodontal bacterial infections in diabetic individuals and contrasting it with non-diabetic people. Patient and method: A case control study conducted at the department of periodontics during a period from February to April 2022. It included 70 subjects divided into four groups according to periodontitis and diabetes. Five ml of salivary sample was taken from each participant for the quantitative determination of salivary procalcitonin. Result: In this study, mean of salivary procalcitonin was significantly higher in GP + T2DM group than that in other groups. It was significantly lower in controls than that in other groups and significantly lower in T2DM group than that in GP + T2DM group. There were significant positive correlations between salivary procalcitonin and all of bleeding on probing, probing pocket depth, and clinical attachment loss. Conclusion: An elevated salivary procalcitonin level has been proposed as a possible biomarker for periodontal disorders because it plays a role in periodontal inflammation. Additionally, subclinical, low grade chronic inflammation in diabetes individuals may be mediated by salivary procalcitonin, a possible proinflammatory mediator.

Keywords

• salivary procalcitonin
• ؛periodontitis
• type 2 diabetes