An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

Benyu Liu; Buqing Ye; Xiaoxiao Zhu; Liuliu Yang; Huimu Li; Nian Liu; Pingping Zhu; Tiankun Lu; Luyun He; Yong Tian; Zusen Fan

doi:10.1038/s41467-020-17944-5

Nature Communications (Aug 2020)

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution

Benyu Liu,
Buqing Ye,
Xiaoxiao Zhu,
Liuliu Yang,
Huimu Li,
Nian Liu,
Pingping Zhu,
Tiankun Lu,
Luyun He,
Yong Tian,
Zusen Fan

Affiliations

Benyu Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Buqing Ye: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiaoxiao Zhu: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Liuliu Yang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Huimu Li: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Nian Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Pingping Zhu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Tiankun Lu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Luyun He: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yong Tian: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Zusen Fan: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-17944-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Type 3 innate lymphoid cells (ILC3) are involved in maintaining gut immune homeostasis. Here the authors identify a circular RNA, circKcnt2, to be induced in ILC3s from inflamed gut, yet circKcnt2 deletion aggravates mouse experimental colitis, thereby implicating circKcnt2 as a potential feedback regulator of ILC3 activation and gut immunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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