Communications Biology (Jan 2023)

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

  • Pyry Helkkula,
  • Shabbeer Hassan,
  • Elmo Saarentaus,
  • Emilia Vartiainen,
  • Sanni Ruotsalainen,
  • Jaakko T. Leinonen,
  • FinnGen,
  • Aarno Palotie,
  • Juha Karjalainen,
  • Mitja Kurki,
  • Samuli Ripatti,
  • Taru Tukiainen

DOI
https://doi.org/10.1038/s42003-022-04285-w
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 12

Abstract

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A genome-wide association study in a Finnish cohort identifies several new loci associated with varicose veins, including the connexin gene family member, GJD3, as a future druggable target.