ANTIFOLATES FOR ANTICANCER CHEMOTHERAPY. PART IІ

Abstract

In the review the structure of the basic antifolate antagonists, their intracellular enzyme tar-gets, and their mechanisms of antitumor activity were considered. Folate antimetabolites, which were discovered in the last decade and trends in finding powerful inhibitors of folic acid metabolic pathways, were discussed in details. The advantages and limitations of antifolates that can be used for the design of new drugs for antitumor chemotherapy were considered.

Keywords

• антифолати, антиметаболіти, протипухлинна хіміотерапія