Modern drugs for obesity and metabolic syndrome treatment (Review)

Abstract

The article reviews modern anti-obesity drugs to identify new trends in effective and safe risk factors reduction (diabetes, cardiovascular and musculoskeletal diseases, cancer). Some anti-obesity drugs have a high risk of adverse effects on the CNS and cardiovascular system, so they should be used for a short-term therapy only. These drugs are cannabinoid receptor antagonists (Rimonabant), neuronal NE and 5-HT reuptake inhibitors (Sibutramine), neuronal NE, 5-HT, DA reuptake inhibitor (Tesofensine), 5HT2с receptors agonist (Lorcaserin) and other drugs affecting the central and peripheral mediator systems. That is why the treatment of obesity should focus on safe drugs that affected fat absorption (Orlistat), activated energy metabolism (Adipokines), methionine aminopeptidase 2 (MetAP2) inhibitors (Beloranib) etc. The combination of anti-obesity drugs with various mechanisms of action increases the effectiveness and reduces adverse effects (Contrave®, Empatic™, Qsymia etс).

Keywords

• modern pharmacotherapy of obesity
• tesofensine
• orlistat
• lorcaserin
• sibutramine
• rimonabant
• beloranib
• liraglutide
• qsymia
• adipokines