Journal of Clinical & Translational Endocrinology (Dec 2018)

Less known aspects of central hypothyroidism: Part 1 – Acquired etiologies

  • Salvatore Benvenga,
  • Marianne Klose,
  • Roberto Vita,
  • Ulla Feldt-Rasmussen

Journal volume & issue
Vol. 14
pp. 25 – 33

Abstract

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Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion. Keywords: Hypopituitarism, Central hypothyroidism, Thyrotropin deficiency, Congenital hypothyroidism