Nature Communications (Apr 2016)
Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
- Zhi Li,
- Tom Hodgkinson,
- Elizabeth J. Gothard,
- Soulmaz Boroumand,
- Rebecca Lamb,
- Ian Cummins,
- Priyanka Narang,
- Amy Sawtell,
- Jenny Coles,
- German Leonov,
- Andrea Reboldi,
- Christopher D. Buckley,
- Tom Cupedo,
- Christian Siebel,
- Ardeshir Bayat,
- Mark C. Coles,
- Carrie A. Ambler
Affiliations
- Zhi Li
- School of Biological and Biomedical Sciences, Biophysical Sciences Institute, Durham University
- Tom Hodgkinson
- Institute for Inflammation and Repair, University of Manchester
- Elizabeth J. Gothard
- Department of Biology and Hull York Medical School, Centre for Immunology and Infection
- Soulmaz Boroumand
- School of Biological and Biomedical Sciences, Biophysical Sciences Institute, Durham University
- Rebecca Lamb
- School of Biological and Biomedical Sciences, Biophysical Sciences Institute, Durham University
- Ian Cummins
- School of Biological and Biomedical Sciences, Biophysical Sciences Institute, Durham University
- Priyanka Narang
- Department of Biology and Hull York Medical School, Centre for Immunology and Infection
- Amy Sawtell
- Department of Biology and Hull York Medical School, Centre for Immunology and Infection
- Jenny Coles
- Department of Biology and Hull York Medical School, Centre for Immunology and Infection
- German Leonov
- Department of Biology and Hull York Medical School, Centre for Immunology and Infection
- Andrea Reboldi
- Department of Microbiology and Immunology, University of California
- Christopher D. Buckley
- MRC Centre for Immune Regulation, University of Birmingham
- Tom Cupedo
- Department of Hematology, Erasmus University Medical Center
- Christian Siebel
- Department of Molecular Biology, Division of Research, Genentech Inc
- Ardeshir Bayat
- Institute for Inflammation and Repair, University of Manchester
- Mark C. Coles
- Department of Biology and Hull York Medical School, Centre for Immunology and Infection
- Carrie A. Ambler
- School of Biological and Biomedical Sciences, Biophysical Sciences Institute, Durham University
- DOI
- https://doi.org/10.1038/ncomms11394
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that promote repair.
