Nature Communications (Apr 2016)

Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

  • Zhi Li,
  • Tom Hodgkinson,
  • Elizabeth J. Gothard,
  • Soulmaz Boroumand,
  • Rebecca Lamb,
  • Ian Cummins,
  • Priyanka Narang,
  • Amy Sawtell,
  • Jenny Coles,
  • German Leonov,
  • Andrea Reboldi,
  • Christopher D. Buckley,
  • Tom Cupedo,
  • Christian Siebel,
  • Ardeshir Bayat,
  • Mark C. Coles,
  • Carrie A. Ambler

DOI
https://doi.org/10.1038/ncomms11394
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that promote repair.