International Journal of Infectious Diseases (May 2023)
Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians
- Polianna Delfino-Pereira,
- Magda Carvalho Pires,
- Virginia Mara Reis Gomes,
- Matheus Carvalho Alves Nogueira,
- Maria Clara Pontello Barbosa Lima,
- Alexandre Vargas Schwarzbold,
- Amanda de Oliveira Maurílio,
- Ana Luiza Bahia Alves Scotton,
- André Soares de Moura Costa,
- Barbara Lopes Farace,
- Bruno Mateus de Castro,
- Christiane Corrêa Rodrigues Cimini,
- Daniel Vitório Silveira,
- Daniela Ponce,
- Elayne Crestani Pereira,
- Eliane Würdig Roesch,
- Euler Roberto Fernandes Manenti,
- Evelin Paola de Almeida Cenci,
- Fernanda Costa dos Santos,
- Fernando Anschau,
- Fernando Graça Aranha,
- Frederico Bartolazzi,
- Guilherme Fagundes Nascimento,
- Heloisa Reniers Vianna,
- Joanna d'Arc Lyra Batista,
- Joice Coutinho de Alvarenga,
- Juliana da Silva Nogueira Carvalho,
- Juliana Machado-Rugolo,
- Karen Brasil Ruschel,
- Luanna Silva Monteiro Menezes,
- Luís César de Castro,
- Luiz Antônio Nasi,
- Maiara Anschau Floriani,
- Maíra Dias Souza,
- Maíra Viana Rego Souza-Silva,
- Marcelo Carneiro,
- Maria Aparecida Camargos Bicalho,
- Mariana Frizzo de Godoy,
- Milton Henriques Guimarães-Júnior,
- Patricia Klarmann Ziegelmann,
- Pedro Ledic Assaf,
- Petrônio José de Lima Martelli,
- Renan Goulart Finger,
- Saionara Cristina Francisco,
- Silvia Ferreira Araújo,
- Talita Fischer Oliveira,
- Thainara Conceição de Oliveira,
- Thalita Martins Lage,
- Vanessa Muller,
- Yuri Carlotto Ramires,
- Teresa Cristina de Abreu Ferrari,
- Milena Soriano Marcolino
Affiliations
- Polianna Delfino-Pereira
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil; Corresponding author:
- Magda Carvalho Pires
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
- Virginia Mara Reis Gomes
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Centro Universitário de Belo Horizonte (UniBH), Belo Horizonte, Brazil
- Matheus Carvalho Alves Nogueira
- Hospitais da Rede Mater Dei, Belo Horizonte, Brazil
- Maria Clara Pontello Barbosa Lima
- Universidade Federal de Ouro Preto, Ouro Preto, Brazil
- Alexandre Vargas Schwarzbold
- Universidade Federal de Santa Maria/Hospital Universitário/EBSERH, Santa Maria, Brazil
- Amanda de Oliveira Maurílio
- Hospital São João de Deus, São João de Deus, Brazil
- Ana Luiza Bahia Alves Scotton
- Hospital Regional Antônio Dias, Patos de Minas, Brazil
- André Soares de Moura Costa
- Hospitais da Rede Mater Dei, Belo Horizonte, Brazil
- Barbara Lopes Farace
- Hospital Risoleta Tolentino Neves, Belo Horizonte, Brazil
- Bruno Mateus de Castro
- Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- Christiane Corrêa Rodrigues Cimini
- Hospital Santa Rosália. R, Teófilo Otoni, Brazil; Mucuri Medical School (FAMMUC), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Teófilo Otoni, Brazil
- Daniel Vitório Silveira
- Hospital Unimed BH, Belo Horizonte, Brazil
- Daniela Ponce
- Faculdade de Medicina de Botucatu - Universidade Estadual Paulista “Júlio de Mesquita Filho”. Av. Prof. Mário Rubens Guimarães Montenegro, s/n - UNESP - Campus de Botucatu, Botucatu, Brazil
- Elayne Crestani Pereira
- Hospital SOS Cárdio, Florianópolis, Brazil
- Eliane Würdig Roesch
- Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- Euler Roberto Fernandes Manenti
- Hospital Mãe de Deus, Porto Alegre, Brazil
- Evelin Paola de Almeida Cenci
- Hospital Universitário Canoas, Canoas, Brazil
- Fernanda Costa dos Santos
- Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Porto Alegre, Brazil
- Fernando Anschau
- Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Porto Alegre, Brazil
- Fernando Graça Aranha
- Hospital SOS Cárdio, Florianópolis, Brazil
- Frederico Bartolazzi
- Hospital Santo Antônio. Praça Dr. Márcio Carvalho Lopes Filho, Curvelo, Brazil
- Guilherme Fagundes Nascimento
- Hospital Unimed BH, Belo Horizonte, Brazil
- Heloisa Reniers Vianna
- Hospital Universitário Ciências Médicas, Belo Horizonte, Brazil
- Joanna d'Arc Lyra Batista
- Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil; Universidade Federal da Fronteira Sul, Chapecó, Brazil; Hospital Regional do Oeste. R. Florianópolis, Chapecó, Brazil
- Joice Coutinho de Alvarenga
- Fundação Hospitalar do Estado de Minas Gerais (FHEMIG). Cidade Administrativa de Minas Gerais, Belo Horizonte, Brazil
- Juliana da Silva Nogueira Carvalho
- Hospital das Clínicas da Universidade Federal de Pernambuco, Recife, Brazil
- Juliana Machado-Rugolo
- Faculdade de Medicina de Botucatu - Universidade Estadual Paulista “Júlio de Mesquita Filho”. Av. Prof. Mário Rubens Guimarães Montenegro, s/n - UNESP - Campus de Botucatu, Botucatu, Brazil
- Karen Brasil Ruschel
- Hospital Mãe de Deus, Porto Alegre, Brazil; Hospital Universitário Canoas, Canoas, Brazil
- Luanna Silva Monteiro Menezes
- Hospital Luxemburgo, Belo Horizonte, Brazil; Hospital Metropolitano Odilon Behrens, Belo Horizonte, Brazil
- Luís César de Castro
- Hospital Bruno Born, Lajeado, Brazil
- Luiz Antônio Nasi
- Hospital Moinhos de Vento, Porto Alegre, Brazil
- Maiara Anschau Floriani
- Hospital Moinhos de Vento, Porto Alegre, Brazil
- Maíra Dias Souza
- Hospital Metropolitano Odilon Behrens, Belo Horizonte, Brazil
- Maíra Viana Rego Souza-Silva
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
- Marcelo Carneiro
- Hospital Santa Cruz, Santa Cruz do Sul, Brazil
- Maria Aparecida Camargos Bicalho
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Fundação Hospitalar do Estado de Minas Gerais (FHEMIG). Cidade Administrativa de Minas Gerais, Belo Horizonte, Brazil
- Mariana Frizzo de Godoy
- Hospital São Lucas PUCRS, Av. Ipiranga, 6690, Porto Alegre, Brazil
- Milton Henriques Guimarães-Júnior
- Hospital Márcio Cunha, Ipatinga, Brazil
- Patricia Klarmann Ziegelmann
- Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil; Hospital Tacchini. R, Bento Gonçalves, Brazil
- Pedro Ledic Assaf
- Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil
- Petrônio José de Lima Martelli
- Hospital das Clínicas da Universidade Federal de Pernambuco, Recife, Brazil
- Renan Goulart Finger
- Hospital Regional do Oeste. R. Florianópolis, Chapecó, Brazil
- Saionara Cristina Francisco
- Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil
- Silvia Ferreira Araújo
- Hospital Semper, Belo Horizonte, Brazil
- Talita Fischer Oliveira
- Hospital Metropolitano Odilon Behrens, Belo Horizonte, Brazil
- Thainara Conceição de Oliveira
- Hospital Universitário Canoas, Canoas, Brazil
- Thalita Martins Lage
- Hospital Márcio Cunha, Ipatinga, Brazil
- Vanessa Muller
- Hospital São Lucas PUCRS, Av. Ipiranga, 6690, Porto Alegre, Brazil
- Yuri Carlotto Ramires
- Hospital Bruno Born, Lajeado, Brazil
- Teresa Cristina de Abreu Ferrari
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
- Milena Soriano Marcolino
- Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil; Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
- Journal volume & issue
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Vol. 130
pp. 31 – 37
Abstract
ABSTRACT: Objectives: To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population. Methods: This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model. Logistic regression models were used to verify the risk factors for mortality in the study group. Results: Among 7,710 hospitalized patients who had COVID-19, 7.2% developed symptoms while admitted for other reasons. Patients with hospital-manifested COVID-19 had a higher prevalence of cancer (19.2% vs 10.8%) and alcoholism (8.8% vs 2.8%) than patients with community-manifested COVID-19 and also had a higher rate of intensive care unit requirement (45.1% vs 35.2%), sepsis (23.8% vs 14.5%), and death (35.8% vs 22.5%) (P <0.05 for all). The factors independently associated with increased mortality in the study group were increasing age, male sex, number of comorbidities, and cancer. Conclusion: Hospital-manifested COVID-19 was associated with increased mortality. Increasing age, male sex, number of comorbidities, and cancer were independent predictors of mortality among those with hospital-manifested COVID-19 disease.
