Nature Communications (Sep 2021)

Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion

  • Xuan Liu,
  • Heming Chen,
  • Yiting Wang,
  • Yueguang Si,
  • Hongxin Zhang,
  • Xiaomin Li,
  • Zhengcheng Zhang,
  • Biao Yan,
  • Su Jiang,
  • Fei Wang,
  • Shijun Weng,
  • Wendong Xu,
  • Dongyuan Zhao,
  • Jiayi Zhang,
  • Fan Zhang

DOI
https://doi.org/10.1038/s41467-021-25993-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Conventional upconversion nanoparticles (UCNPs) cannot activate multiple neuron populations independently using optogenetics. Here the authors report trichromatic UCNPs with excitation-specific luminescence to allow activation of three distinct neuronal populations in the brain of awake mice.