The Role of Obesity in Predicting the Clinical Outcomes of COVID-19
Serdar Sahin,
Havva Sezer,
Ebru Cicek,
Yeliz Yagız Ozogul,
Murat Yildirim,
Tevhide Betul Icli,
Ozge Polat Korkmaz,
Emre Durcan,
Cem Sulu,
Kayra Somay,
Bahar Bekdemir,
Sermin Borekci,
Dilek Yazici,
Oguzhan Deyneli,
Onder Ergonul,
Fehmi Tabak,
Yalim Dikmen,
Hande Mefkure Ozkaya,
Mustafa Sait Gonen,
Taner Damci,
Hasan Ilkova,
Volkan Demirhan Yumuk
Affiliations
Serdar Sahin
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Havva Sezer
European Association for the Study of Obesity – Collaborating Center for Obesity Management, Istanbul, Turkey
Ebru Cicek
Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Yeliz Yagız Ozogul
Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Murat Yildirim
Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Tevhide Betul Icli
Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Ozge Polat Korkmaz
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Emre Durcan
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Cem Sulu
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Kayra Somay
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey
Bahar Bekdemir
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey
Sermin Borekci
Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Dilek Yazici
European Association for the Study of Obesity – Collaborating Center for Obesity Management, Istanbul, Turkey
Oguzhan Deyneli
European Association for the Study of Obesity – Collaborating Center for Obesity Management, Istanbul, Turkey
Onder Ergonul
Department of Infectious Diseases and Clinical Microbiology, Koç University School of Medicine, Istanbul, Turkey
Fehmi Tabak
Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Yalim Dikmen
Department of Anesthesiology and Reanimation, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Hande Mefkure Ozkaya
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Mustafa Sait Gonen
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Taner Damci
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Hasan Ilkova
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University – Cerrahpasa, Istanbul, Turkey
Introduction: The aim of this was to describe the predictors of mortality related to COVID-19 infection and to evaluate the association between overweight, obesity, and clinical outcomes of COVID-19. Methods: We included the patients >18 years of age, with at least one positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction. Patients were grouped according to body mass index values as normal weight <25 kg/m2 (Group A), overweight from 25 to <30 kg/m2 (Group B), Class I obesity 30 to <35 kg/m2 (Group C), and ≥35 kg/m2 (Group D). Mortality, clinical outcomes, laboratory parameters, and comorbidities were compared among 4 groups. Results: There was no significant difference among study groups in terms of mortality. Noninvasive mechanical ventilation requirement was higher in group B and D than group A, while it was higher in Group D than Group C (Group B vs. Group A [p = 0.017], Group D vs. Group A [p = 0.001], and Group D vs. Group C [p = 0.016]). Lung involvement was less common in Group A, and presence of hypoxia was more common in Group D (Group B vs. Group A [p = 0.025], Group D vs. Group A [p < 0.001], Group D vs. Group B [p = 0.006], and Group D vs. Group C [p = 0.014]). The hospitalization rate was lower in Group A than in the other groups; in addition, patients in Group D have the highest rate of hospitalization (Group B vs. Group A [p < 0.001], Group C vs. Group A [p < 0.001], Group D vs. Group A [p < 0.001], Group D vs. Group B [p < 0.001], and Group D vs. Group C [p = 0.010]). Conclusion: COVID-19 patients with overweight and obesity presented with more severe clinical findings. Health-care providers should take into account that people living with overweight and obesity are at higher risk for COVID-19 and its complications.
