Multi-scale hierarchical brain regions detect individual and interspecies variations of structural connectivity in macaque monkeys and humans
Kazuya Ouchi,
Daisuke Yoshimaru,
Aya Takemura,
Shinya Yamamoto,
Ryusuke Hayashi,
Noriyuki Higo,
Makoto Obara,
Yasuko Sugase-Miyamoto,
Tomokazu Tsurugizawa
Affiliations
Kazuya Ouchi
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan; Faculty of Engineering, Information and Systems, University of Tsukuba, Ibaraki 305-8573, Japan
Daisuke Yoshimaru
Faculty of Engineering, Information and Systems, University of Tsukuba, Ibaraki 305-8573, Japan; Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato City Tokyo 105-8461, Japan
Aya Takemura
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan
Shinya Yamamoto
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan; Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8577, Japan
Ryusuke Hayashi
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan
Noriyuki Higo
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan
Makoto Obara
Philips Japan, 2-13-37 Kohnan, Minato-ku 108-8507, Tokyo, Japan
Yasuko Sugase-Miyamoto
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan
Tomokazu Tsurugizawa
Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba-City, Ibaraki 305-8568, Japan; Faculty of Engineering, Information and Systems, University of Tsukuba, Ibaraki 305-8573, Japan; Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato City Tokyo 105-8461, Japan; Corresponding author.
Macaques are representative animal models in translational research. However, the distinct shape and location of the brain regions between macaques and humans prevents us from comparing the brain structure directly. Here, we calculated structural connectivity (SC) with multi-scale hierarchical regions of interest (ROIs) to parcel out human and macaque brain into 8 (level 1 ROIs), 28 (level 2 ROIs), or 46 (level 3 ROIs) regions, which consist of anatomically and functionally defined level 4 ROIs (around 100 parcellation of the brain). The SC with the level 1 ROIs showed lower individual and interspecies variation in macaques and humans. SC with level 2 and 3 ROIs shows that the several regions in frontal, temporal and parietal lobe show distinct connectivity between macaques and humans. Lateral frontal cortex, motor cortex and auditory cortex were shown to be important areas for interspecies differences. These results provide insights to use macaques as animal models for translational study.
