Frontiers in Endocrinology (Feb 2023)
An elevated parametric thyroid feedback quantile-based index is associated with atrial fibrillation
- Vanesa Alonso-Ventura,
- Vanesa Alonso-Ventura,
- Vanesa Alonso-Ventura,
- Patricia Campos-Magallon,
- Belen Moreno-Franco,
- Belen Moreno-Franco,
- Belen Moreno-Franco,
- Belen Moreno-Franco,
- Pilar Calmarza,
- Pilar Calmarza,
- Pilar Calmarza,
- Pilar Calmarza,
- Fernando Calvo-Gracia,
- Fernando Calvo-Gracia,
- Fernando Calvo-Gracia,
- Jose Manuel Lou-Bonafonte,
- Jose Manuel Lou-Bonafonte,
- Jose Manuel Lou-Bonafonte,
- Jose Manuel Lou-Bonafonte,
- Patricia de Diego-Garcia,
- Patricia de Diego-Garcia,
- Jose Antonio Casasnovas,
- Jose Antonio Casasnovas,
- Jose Antonio Casasnovas,
- Jose Antonio Casasnovas,
- Victoria Marco-Benedi,
- Victoria Marco-Benedi,
- Victoria Marco-Benedi,
- Victoria Marco-Benedi,
- Fernando Civeira,
- Fernando Civeira,
- Fernando Civeira,
- Fernando Civeira,
- Martin Laclaustra,
- Martin Laclaustra,
- Martin Laclaustra,
- Martin Laclaustra
Affiliations
- Vanesa Alonso-Ventura
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Vanesa Alonso-Ventura
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Vanesa Alonso-Ventura
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Patricia Campos-Magallon
- Hospital San Pedro, Logroño, Spain
- Belen Moreno-Franco
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Belen Moreno-Franco
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Belen Moreno-Franco
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Belen Moreno-Franco
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares-Instituto de Salud Carlos III (CIBERCV-ISCIII), Madrid, Spain
- Pilar Calmarza
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Pilar Calmarza
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Pilar Calmarza
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Pilar Calmarza
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares-Instituto de Salud Carlos III (CIBERCV-ISCIII), Madrid, Spain
- Fernando Calvo-Gracia
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Fernando Calvo-Gracia
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Fernando Calvo-Gracia
- Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
- Jose Manuel Lou-Bonafonte
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Jose Manuel Lou-Bonafonte
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Jose Manuel Lou-Bonafonte
- Instituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, Zaragoza, Spain
- Jose Manuel Lou-Bonafonte
- Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición-Instituto de Salud Carlos III (CIBEROBN-ISCIII), Madrid, Spain
- Patricia de Diego-Garcia
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Patricia de Diego-Garcia
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Jose Antonio Casasnovas
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Jose Antonio Casasnovas
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Jose Antonio Casasnovas
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Jose Antonio Casasnovas
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares-Instituto de Salud Carlos III (CIBERCV-ISCIII), Madrid, Spain
- Victoria Marco-Benedi
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Victoria Marco-Benedi
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Victoria Marco-Benedi
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Victoria Marco-Benedi
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares-Instituto de Salud Carlos III (CIBERCV-ISCIII), Madrid, Spain
- Fernando Civeira
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Fernando Civeira
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Fernando Civeira
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Fernando Civeira
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares-Instituto de Salud Carlos III (CIBERCV-ISCIII), Madrid, Spain
- Martin Laclaustra
- Hospital Universitario Miguel Servet, Zaragoza, Spain
- Martin Laclaustra
- Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain
- Martin Laclaustra
- Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
- Martin Laclaustra
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares-Instituto de Salud Carlos III (CIBERCV-ISCIII), Madrid, Spain
- DOI
- https://doi.org/10.3389/fendo.2023.1087958
- Journal volume & issue
-
Vol. 14
Abstract
IntroductionAtrial fibrillation is associated with hyperthyroidism. Within the euthyroid range, it is also associated with high thyroxine (fT4), but not with thyrotropin (TSH). We aim to describe differences in thyroid regulation, measured by the Parametric Thyroid Feedback Quantile-Based Index (PTFQI), between patients with atrial fibrillation and the general population.Materials and methodsThyroid parameters (PTFQI, TSH, and fT4) of a sample of 84 euthyroid subjects with atrial fibrillation (cases) were compared to a reference sample of euthyroid healthcare patients (controls). We calculated age and sex adjusted ORs for atrial fibrillation across tertiles of these parameters. Also, within cases, we studied thyroid parameters association with clinical characteristics of the atrial fibrillation.ResultsAfter adjusting for age and sex, fT4 and PTFQI were higher in subjects with atrial fibrillation when compared to the general sample (p<0.01 and p=0.01, respectively). Atrial fibrillation ORs of the third versus the first PTFQI tertile was 1.88(95%CI 1.07,3.42), and there was a gradient across tertiles (p trend=0.02). Among atrial fibrillation patients, we observed that higher PTFQI was associated with sleep apnea/hypopnea syndrome (OSAS) (p=0.03), higher fT4 was associated with the presence of an arrhythmogenic trigger (p=0.02) and with heart failure (p<0.01), and higher TSH was also associated with OSAS (p<0.01).ConclusionsEuthyroid subjects with atrial fibrillation have an elevation of the pituitary TSH-inhibition threshold, measured by PTFQI, with respect to the general population. Within atrial fibrillation patients, high PTFQI was associated with OSAS, and high fT4 with heart failure. These results hint of the existence of a relationship between thyroid regulation and atrial fibrillation.
Keywords
- atrial fibrillation
- thyroid regulation
- thyrotropin
- thyroxine
- Parametric Thyroid Feedback Quantile-Based Index
- PTFQI