Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

Bruno Bernardes de Jesus; Sérgio Pires Marinho; Sara Barros; António Sousa-Franco; Catarina Alves-Vale; Tânia Carvalho; Maria Carmo-Fonseca

doi:10.1038/s41467-017-01921-6

Nature Communications (Jan 2018)

Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

Bruno Bernardes de Jesus,
Sérgio Pires Marinho,
Sara Barros,
António Sousa-Franco,
Catarina Alves-Vale,
Tânia Carvalho,
Maria Carmo-Fonseca

Affiliations

Bruno Bernardes de Jesus: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Sérgio Pires Marinho: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Sara Barros: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
António Sousa-Franco: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Catarina Alves-Vale: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Tânia Carvalho: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
Maria Carmo-Fonseca: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa

DOI: https://doi.org/10.1038/s41467-017-01921-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The efficiency of somatic cell reprogramming is lowered by ageing. Here the authors show that the transcription factor Zeb2 and its long non-coding RNA Zeb2-NAT are expressed at high levels in older fibroblasts and their inhibition increases reprogramming efficiency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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