Nature Communications (Apr 2016)

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

  • Alexei Brooun,
  • Ketan S. Gajiwala,
  • Ya-Li Deng,
  • Wei Liu,
  • Ben Bolaños,
  • Patrick Bingham,
  • You-Ai He,
  • Wade Diehl,
  • Nicole Grable,
  • Pei-Pei Kung,
  • Scott Sutton,
  • Karen A. Maegley,
  • Xiu Yu,
  • Al E. Stewart

DOI
https://doi.org/10.1038/ncomms11384
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.