Nature Communications (Jan 2022)
Carbene-catalyzed atroposelective synthesis of axially chiral styrenes
Abstract
Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to prepare due to low rotational barrier of the axis. Here the authors present a method to form axially chiral styrenes bearing sulfones and carboxylic acids via NHC catalysis.