Nature Communications (Feb 2023)
Integrative proteomic characterization of adenocarcinoma of esophagogastric junction
- Shengli Li,
- Li Yuan,
- Zhi-Yuan Xu,
- Jing-Li Xu,
- Gui-Ping Chen,
- Xiaoqing Guan,
- Guang-Zhao Pan,
- Can Hu,
- Jinyun Dong,
- Yi-An Du,
- Li-Tao Yang,
- Mao-Wei Ni,
- Rui-Bin Jiang,
- Xiu Zhu,
- Hang Lv,
- Han-Dong Xu,
- Sheng-Jie Zhang,
- Jiang-Jiang Qin,
- Xiang-Dong Cheng
Affiliations
- Shengli Li
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Li Yuan
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Zhi-Yuan Xu
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Jing-Li Xu
- First Clinical Medical College, Zhejiang Chinese Medical University
- Gui-Ping Chen
- Department of Gastrointestinal Surgery, the First Affiliated Hospital of Zhejiang Chinese Medical University
- Xiaoqing Guan
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Guang-Zhao Pan
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Can Hu
- First Clinical Medical College, Zhejiang Chinese Medical University
- Jinyun Dong
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Yi-An Du
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Li-Tao Yang
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Mao-Wei Ni
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Rui-Bin Jiang
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Xiu Zhu
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Hang Lv
- Biological Sample Bank, the First Affiliated Hospital of Zhejiang Chinese Medical University
- Han-Dong Xu
- First Clinical Medical College, Zhejiang Chinese Medical University
- Sheng-Jie Zhang
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Jiang-Jiang Qin
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- Xiang-Dong Cheng
- Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-023-36462-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
The molecular subtypes of adenocarcinoma of the esophagogastric junction (AEG) remain to be identified. Here, the authors perform proteogenomic characterisation of AEG tumours with paired normal adjacent tissues and suggest three proteomic subtypes and potential druggable targets.
