Ruthenium-based Photocatalysis in Templated Reactions
Jacques Saarbach,
Eric Lindberg,
Nicolas Winssinger
Affiliations
Jacques Saarbach
Faculty of Science, Department of Organic Chemistry NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. [email protected]
Eric Lindberg
Faculty of Science, Department of Organic Chemistry NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland
Nicolas Winssinger
Faculty of Science, Department of Organic Chemistry NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. [email protected]
Templated reactions proceed by bringing reagents in close proximity through their interaction with a template thus raising their effective concentrations. Templated reactions empower chemists to perform reactions at low concentrations in complex environments. Herein, we discuss our work on templated reactions leveraged on ruthenium photocatalysis. Over the past five years, we have used this reaction to uncage reporter molecules and sense or image nucleic acids or proteins of interest. The ruthenium photocatalysis chemistry has proven to be extremely robust and compatible with complex biological environments.
